Statins are the only cholesterol drugs that have been clearly shown to reduce mortality that is, to save lives. Atorvastatin and simvastatin are medications that treat high blood cholesterol and triglycerides. While zetia does lower cholesterol, there is to date no convincing evidence that it saves lives. In the statin therapies for elevated lipid levels compared across doses to rosuvastatin stellar trial, the efficacy of rosuvastatin calcium crestor was compared with that of atorvastatin lipitor, simvastatin zocor, and pravastatin pravachol for lowering plasma lowdensity lipoprotein cholesterol ldlc after 6 weeks of treatment. Take lipitor each day at any time of day at about the same time each day. Compare lipitor vs simvastatin comprehensive analysis by. Hmgcoa reductase inhibitors or statins are potent hypocholesterolemic drugs. Mar 16, 2009 ezetimibe simvastatin mk0653a versus rosuvastatin versus doubling statin dose in participants with cardiovascular disease and diabetes mellitus mk0653a3completed the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Pravachol pravastatin can improve cholesterol, but its not as. Compare atorvastatin vs lovastatin vs pravastatin vs.
Although in this study doctors were given the choice of which simvastatin dose to swap the patients taking 10 mg atorvastatin to, following the heart protection study there is a growing consensus, as highlighted in a recent article in the british medical journal, that all patients taking both 10 and 20 mg atorvastatin should be switched to 40. Efficacy and safety of rosuvastatin and atorvastatin. Comparison of pitavastatin with atorvastatin in increasing hdlcholesterol and adiponectin in patients with dyslipidemia and coronary artery disease compactcad was a 30month randomized, nonblinded, multicenter study of patients with stable cad. Lower cardiovascular mortality with atorvastatin and rosuvastatin vs simvastatin. Lipitor atorvastatin can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking. Pfizer inc despite a significant cost differential and no apparent clinical differences in efficacy and safety. In general, both these medications lower bad cholesterol and triglycerides and increase good cholesterol in the process. Overall adherence, defined as total study medication exposure as a percentage of total followup time, was 89% in the atorvastatin group and 95% in the simvastatin group.
On the discharge order was zocor 20mg dailyand the patient probably got the prescription filled. Learn about drug interactions between atorvastatin oral and simvastatin oral and use the rxlist drug interaction checker to check drug combinations. August 3, 2019 august 3, 2019 by your health remedys staff. Atorvastatin vs simvastatin uses, side effects, differences. And because generic versions of drugs tend to be cheaper than the brandname ones, most people consider of switching from lipitor to simvastatin. Altast elevations 3 x uln occurred in 1% of patients in the atorvastatin arm and 0.
In 2011, fewer prescriptions for generic simvastatin were written than for lipitor atorvastatin calcium. Highdose atorvastatin in acute coronary and cerebrovascular. In these trials, there was no lower limit to ldl for eligibility, supporting treatment with a statin regardless of the ldl level. Changes in lipoprotein particle concentration may predict the risk of coronary heart disease more accurately than lipoprotein cholesterol levels. Weekly versus daily dosing of atorvastatin mdedge family. Six of the included studies used this method to merge two dosage groups of the same statin treatment 19, 2428.
Lipitor significantly reduced the rate of major cardiovascular events primary endpoint events 83 events in the lipitor group vs. Doctors give trusted answers on uses, effects, sideeffects, and cautions. Efficacy of atorvastatin compared with simvastatin in. Simvastatin is sold under the name zocor, and lipitor as atorvastatin calcium. Unfortunately, despite the fact that 80 mg atorvastatin was associated with a 46% reduction in the primary end point death, nonfatal mi, and tvr, the study was not nearly powered enough to assess this end point, because these events occurred in only 9 patients in the lowdose atorvastatin group compared with 5 events in the highdose group. And at home, the patient started to resume old home med as instructed. This ldlclowering effect has been verified in several. It belongs to a group of drugs known as hmgcoa reductase inhibitors statins. These reduce the plasma concentration of simvastatin and atorvastatin and may reduce their effectiveness. Comparative dose efficacy study of atorvastatin versus.
Atorvastatin, a wellestablished statin, has been shown to be effective in lowering ldlc levels as much as 61% at a dose of 80mg. Of the three components of the primary endpoint, nonfatal mi was significantly reduced. Hemostatic effects of atorvastatin versus simvastatin. Lipitor atorvastatin is a good option for people who have high cholesterol and diabetes. Highdose atorvastatin vs usualdose simvastatin for. Ezetimibesimvastatin mk0653a versus rosuvastatin versus. Atorvastatin lipitor 40mg or lipitor 80mg if you have had a heart attack or have acute coronary syndrome and your ldl is highly elevated. Percent change in tav primary end point was significantly smaller in the atorvastatin group than in the rosuvastatin group 3. The study reported a significant inhibitory effect of atorvastatin on clopidogrel antiplatelet. What are the differences between atorvastatin and simvastatin. This leaflet answers some of the more common questions about atorvastatin. The agency singled out atorvastatin lipitor, rosuvastatin crestor, and simvastatin zocor for the new warnings and restated a warning about mixing lovastatin mevacor with hiv and hcv drugs. Compare lipitor vs simvastatin comprehensive analysis by treato. This also has the effect of lowering the total amount of ldl cholesterol.
Comparison of simvastatin and atorvastatin 683 starting dose simvastatin 20 rng atorvastatin 10 rng simvastatin 40 mg atorvastatin 20 rng randomization i higher dose statin 20 to40 mgday for an average of 5. Pdf highdose atorvastatin vs usualdose simvastatin for. Compare lipitor vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Reducing ldl cholesterol slows progression and may reverse coronary artery disease. Compare atorvastatin vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Pdf effects of atorvastatin and simvastatin on atrial. An overview of ideal a comparison of intensive statin vs. While the former drug is also available as a generic, the latter is not. Todays fda safety communication follows label changes announced tuesday that added cautions about new onset diabetes and transient memory problems. Statin conversion chart % ldl reduction simvastatin zocor atorvastatin lipitor rosuvastatin crestor fluvastatin lescol lovastatin mevacor pravastatin pravachol ezetimibesimvastatin vytorin atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p atorvastatin 10 mg than for simvastatin 10 mg 37.
The differences between these two treatments are the differences in the medications themselves. Zocor, on the other hand is called simvastatin with a empirical formula of c25h38o5 and a molecular weight of 418. Patient got discharged and was instructed to resume home meds. Simvastatin is part of a group of drugs known as statins that reduce levels of ldl cholesterol in the blood while increasing levels. Enrollment and randomization were carried out from september 2008 to september 2009. Atorvastatin vs simvastatin what does the doctor say. The lipid modification effects appeared to be similar to pravastatin, simvastatin, lovastatin, atorvastatin, or fluvastatin. It reduces ldl and total cholesterol levels while increasing levels of hdl cholesterol.
Apr 04, 2020 atorvastatin and simvastatin are medications that treat high blood cholesterol and triglycerides. However, this is over four times more expensive than generic simvastatin 40mg. Simvastatin oral tablet is available as the brandname drug zocor. Objective the purpose of this study was to examine the effects of statin therapy on lipoprotein particle concentrations in patients with the metabolic syndrome. Furthermore, atorvastatin demonstrates prolonged inhibition of hmgcoa reductase compared with other statins, presumably because of longer residence of the drug or its metabolites in the liver. Lipitor reduces total cholesterol and ldl bad cholesterol, which is largely responsible for the development of coronary artery disease. The dosage range of lipitor is 10 to 80 mg once daily. Aug 15, 2011 type 1 1996, pumping since 110411, medtronic minimed 670g cgm guardian. Its one of the strongest cholesterollowering statin medications. To the editor in their commentary on generic drug use, alldredge and kayser 1 p233 state the following. Letude prove ittimi22, ou larroseur arrose revue medicale. Effects of atorvastatin 10 mg and simvastatin 20 mg on serum. Why physicians favored lipitor over simvastatin clinical. Lipitor atorvastatin improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease.
Nnh112 atorvastatin 80mg vs 10mg in the tnttrial n10,001 4. It is marketed under the brand name lipitor and is produced by pfizer. An effect of lipitor was seen regardless of age, sex, or baseline lipid levels. However, there have been isolated case reports of rhabdomyolysis when they have been used in combination with simvastatin. Lipitor atorvastatin and zocor simvastatin are belong to the statin family of drugs that work to lower blood cholesterol, thereby treating a host of cardiovascular conditions, including congestive heart failure prevention. Lipitor and zocor are statins used to treat high blood pressure and heart diseases that can lead to heart attack. Latozet combine deux principes actifs, latorvastatine et lezetimibe, inhi. Effects of rosuvastatin and atorvastatin on ldl and hdl. Bliss, rph, mba and the healthline editorial team side. Of these, 17 received atorvastatin 2040 mg daily, 8 simvastatin 1020 mg daily and 22 no statins. Plaque regression percent change in tav 0% was less frequently observed in the atorvastatin. Atorvastatin belongs to a group of drugs called hmg coa reductase inhibitors.
Efficacy of milligramequivalent doses of atorvastatin. Comparison of pitavastatin with atorvastatin in increasing. Pdf lower cardiovascular mortality with atorvastatin and. Comparative efficacy and safety of lowdose pitavastatin versus atorvastatin in patients with hypercholesterolemia article pdf available in annals of pharmacotherapy 443. Mevacor lovastatin can improve cholesterol, but its not as strong as other statin medicines. Comparison of effects of atorvastatin 20 mg versus. Mar 01, 2011 generic simvastatin 20mg or 40mg daily would seem a reasonable first choice, and nice have used this in their cost estimates. Atorvastatin versus simvastatin tips and tricks from doctors. If you miss a dose of lipitor, take it as soon as you remember. Atorvastatin 10mg daily would be a reasonable alternative. Research design and methods patients with dyslipidemia and the metabolic. The right statin for you will depend on your ldl level and risk factors for heart disease.
The recommended starting dose of lipitor is 10 or 20 mg once daily. The primary endpoint of major coronary event was not significantly reduced by atorvastatin compared with simvastatin. Atorvastatin is a member of the drug class known as statins, used for lowering cholesterol and thereby reducing cardiovascular disease. Effective analysis of atorvastatin versus in simvastatin patients with hyperlipidemia palanisamy pasupathia, g.
Atorvastatin inhibits a ratedetermining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced. Is atorvastatin better than simvastatin doctor answers on. Its available as a generic drug and can be used in combination with other cholesterol lowering drugs. Crestor vs lipitor vs zocor which statin is better for you. Generically, lipitor is called atorvastatin calcium and its empirical formula is c33h34 fn2o52ca3h2o with a molecular weight of 1209.
Lipitor significantly reduced the rate of coronary events either fatal coronary heart disease 46 events in the placebo group vs. Sample sizes were calculated based on the 2sided dunnetts test with a significance level of 5% and a standard deviation of % to detect differences in ldl cholesterol reductions of 8% e. Hospital and post graduate medical institute, coimbatore641 018, tamil nadu, india. In this multicenter, parallelgroup, openlabel trial. Atorvastatin is used together with diet to lower blood levels of bad cholesterol lowdensity lipoprotein, or ldl, to increase levels of good cholesterol highdensity lipoprotein, or hdl, and to lower triglycerides a type of fat in the blood atorvastatin is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type.
Comparison tolerability sirnvastatin atorvastatin in. Highdose atorvastatin vs usualdose simvastatin for secondary prevention after myocardial infarction. Statin side effects can be difficult to deal with, but the benefits might outweigh the risks. Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking. Jun 10, 2006 the maximum price of simvastatin 40 mg is now up to six times cheaper than atorvastatin. Efficacy and safety of rosuvastatin versus atorvastatin in.
There were no significant differences between the treatment groups for allcause mortality. Atorvastatin, pravastatin, simvastatin across dose ranges stellar the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Atorvastatin lipitor, generics na 10 to 20 mg max dose 10 mg, with caution, in patients with a history of renal insufficiency, or crcl atorvastatin 10 mg versus simvastatin 20 mg and atorvastatin 80 mg versus simvastatin 80 mg was determined in a 6week, prospective, randomized, openlabel, blinded endpoint trial of dyslipidemic patients with and without. To evaluate and compare the efficacy and safety of rosuvastatin versus atorvastatin in a highrisk chinese population with hypercholesterolemia. In the secondary analysis, which compared the efficacy of atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p atorvastatin 10 mg than for simvastatin 10 mg 37. The current study demonstrated that rosuvastatin had greater efficacy than atorvastatin in producing favorable changes in the atherogenic lipid profile in highrisk patients with hypercholesterolemia. Pdf hemostatic effects of atorvastatin versus simvastatin. Generic pravastatin is an attractive alternative based on cost.
The proportions of subjects who experienced cv or noncv death were similar for the lipitor 80 mg group and the simvastatin 2040 mg group. Platelet activity was assessed measuring surface pselectin expression using flow cytometry after ex vivo platelet stimulation with adp. Le medicament du mois combinaison fixe atorvastatine. Atorvastatin and simvastatin are parts of a group of drugs called statins that revolutionized cholesterol management and heart disease prevention atorvastatin and simvastatin both target the same chemical in the body to reduce drastically the bloodstream levels of ldl lowdensity lipoprotein, or bad cholesterol, which lowers the risk it will clog up arteries, a central cause of. If your cholesterol is only slightly elevated above what your doctor thinks is a good target for you, a. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Aug 03, 2019 atorvastatin vs simvastatin which is better. This 6 week, prospective, multicenter, doubleblind, threearm, parallelgroup, activecontrolled study randomized adult chinese patients lowdensity lipoprotein cholesterol ldlc. Patients who require a large reduction in ldlc more than 45% may be started at 40 mg once daily. Your doctor should start you on a lowfat diet before giving you lipitor.